Functionally assessing coronavirus entry
نویسندگان
چکیده
منابع مشابه
HTCC: Broad Range Inhibitor of Coronavirus Entry
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, alth...
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UNLABELLED In addition to transporting ions, the multisubunit Na(+),K(+)-ATPase also functions by relaying cardiotonic steroid (CTS)-binding-induced signals into cells. In this study, we analyzed the role of Na(+),K(+)-ATPase and, in particular, of its ATP1A1 α subunit during coronavirus (CoV) infection. As controls, the vesicular stomatitis virus (VSV) and influenza A virus (IAV) were included...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2020
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-020-0847-y